Lithium in drinking water and Alzheimer’s dementia

Bipolar DisordersScott Cunningham MD PhD, et al. | September 09, 2022



Six drugs are FDA-approved for use in patients with AD. While all of the drugs slow the progression of AD, none of the drugs stop the progression of or reverse AD. Preliminary evidence suggests that lithium has a potential role in the prevention and treatment of AD.

The lithium levels in drinking water were measured in 808 cities and wards in Japan The prevalence of AD was determined between 2010 and 2014, and compared to the lithium levels for the total, male, female, and elderly populations.

An inverse association between lithium levels in drinking water and AD existed in females, but not males.