A medicines optimization tool to protect the physical health of people with severe mental illness

BMC PsychiatryScott Cunningham MD PhD, et al. | September 12, 2022



Patients with severe mental illnesses, such as schizophrenia, schizoaffective disorder, bipolar disorder, and severe affective disorders, have a life expectancy up to 30 years less than individuals without a mental illness.

The longevity gap and health inequality between individuals with and without severe mental illness can be narrowed through recommended screening, preventive care, and a focus on modifiable risk factors.

The literature was searched for studies involving optimal medication recommendations and management of medical conditions in patients with severe mental illness. The Delphi consensus technique was used to help construct and validate the OPTIMISE tool, which initially included 83 relevant indicators.

Sixty-two prescribing indicators were selected for the final OPTIMISE tool. Substantial agreement was achieved among physicians and pharmacists, with a kappa statistic = 0.75.