Temporally ordered associations between type 2 diabetes and brain disorders

BMC PsychiatryScott Cunningham MD PhD, et al. | September 14, 2022



T2DM affects > 6% of the global population, and the prevalence of T2DM has increased by 50% over the past 3 years. T2DM is the 9th leading cause of mortality worldwide.

In addition to the association between T2DM and cardiovascular and premature deaths, the current study showed that T2DM is associated with insulinopathies of the brain.

This was a population-based cohort study involving 1,883,198 individuals born between 1955 and 1984, and followed through 2016. The temporal associations between T2DM and 16 brain disorders were determined.

Of the 1,883,198 study participants, 67,660 (3.6%) developed T2DM after 30 years of age (mean age, 45 years).

T2DM was shown to be associated with most psychiatric disorders, but most often with eating (OR=2.64) and schizophrenic spectrum disorders (OR=273).

Of neurodegenerative disorders, T2DM was most often associated with inflammatory brain disorders (OR=1.73) and epilepsy (OR=1.67).